With a spot in the quarter-finals up for grabs the focus for the remaining 16 teams will be on ensuring that they're in the hat for the next round and in with a shout of pushing towards the final stages of the competition.
The week's action gets underway with three ties taking place in the capital on Tuesday evening.
Arsenal host Leeds United at the Emirates Stadium (7.45pm) after defeating AFC Wimbledon 3-0 in the last round.
talkSPORT will also provide updates from QPR's clash with Sunderland at the Kiyan Prince Stadium.
Thomas Tuchel's Chelsea invite Southampton to Stamford Bridge on Tuesday evening as they look to continue their stunning start to the new season.
Full commentary will be available on talkSPORT 2 with Joe Shennan and Danny Mills providing the coverage.
On Wednesday evening there will be five matches being played in the Carabao Cup fourth round.
Reigning champions Manchester City travel to East London to take on West Ham United at the London Stadium.
Burnley host Tottenham Hotspur at Turf Moor with commentary coming on talkSPORT via Jim Proudfoot and Micky Gray.
Elsewhere Leicester City host Brighton, Brentford travel to take on Stoke City while Jurgen Klopp's Liverpool will take on Preston.
Carabao Cup fourth round draw:
Tuesday, October 26
Arsenal vs Leeds (live on talkSPORT)
Chelsea v Southampton (live on talkSPORT 2)
QPR vs Sunderland
Wednesday, October 27