The England captain is thriving in Germany after making the move from Tottenham this summer and he is already breaking records.
Kane has scored 12 goals in only nine games for Bayern which is a tally that has never been achieved across so few matches in the league.
That form has helped Thomas Tuchel's side remain unbeaten so far this campaign, sitting second in the table behind Leverkusen.
Dortmund are also undefeated this season but they are down in fourth, two points behind their bitter rivals ahead of the Der Klassiker.
It sets up what should be a thrilling derby between the two as they aim to maintain their impressive starts.
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Dortmund vs Bayern: Head-to-head history and form
Bayern have dominated the Der Klassiker in recent years, winning eight of the last ten league games against Dortmund.
They have controlled the Bundesliga in that time with their rivals struggling to keep up with their quality.
BVB's last league win came in November 2018 when they won 3-2 after goals from Marco Reus and Paco Alcacer turned the game around.
Away from the Bundesliga, Dortmund's last win still came four years ago, with Bayern not losing in any competition against them since then.
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Ahead of the latest meeting, Bayern come into the clash after incredibly winning 8-0 last weekend.
Kane scored a hat-trick while Jamal Musiala and Leroy Sane both hit doubles and Thomas Muller got in on the act.
Dortmund drew against Frankfurt thanks to a late strike from Julian Brandt saving them from losing for the first time this season.
Dortmund vs Bayern: Team news
Mats Hummels and Gregor Kobel both suffered knocks against Frankfurt last time out meaning they are a doubt for Dortmund.
They could join Felix Nmecha, Emre Can and Mateu Morey in the treatment room.
Donyell Malen and Giovanni Reyna were both substituted at half time last weekend with their starting place being challenged by Karim Adeyemi and Youssoufa Moukoko.
As for Bayern, Kimmich is suspended after receiving an early red card against Darmstadt.
Dayot Upamecano, Raphael Guerreiro and Leon Goretzka will also all miss out after suffering injuries.
Goalkeeper Manuel Neuer is finally back from a leg break and he will feature in his first Der Klassiker since returning.
Dortmund vs Bayern: What has been said?
Kane scored a spectacular goal from the halfway line last time out as he hit a hat-trick in an 8-0 win over Darmstadt.
Speaking about the goal, he said: "I turned on the ball and I just saw the goalkeeper in a strange position out of the corner of my eye.
"We were 4-0 up at the time so I thought why not have a shot?
"As the ball was in the air, I was just praying for it to dip just below the bar and thankfully it did."
Dortmund vs Bayern: How to follow
This Bundesliga clash will take place on Saturday, November 4.
Kick-off at Signal Iduna Park is scheduled for 5:30pm UK time.
The game will be broadcast live on Sky Sports Football with coverage beginning at 5:20pm.
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Sky Sports customers can live stream this via the app using their mobile, tablet or computer device. You can also purchase a Sky Sports Day Pass from NowTV for £11.98
talkSPORT and talkSPORT.com will also have all the reaction post-game.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream. You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.