It could be a huge point for Eddie Howe's men in the 'Group of Death', which also contains Paris Saint-Germain and Borussia Dortmund, as they claimed the hard-fought draw at the San Siro.
But they didn't half ride their luck as the home side missed a series of chances, with Rafael Leao particularly guilty of lacking composure on Tuesday night.
The Magpies nearly won it in stoppage time as Sean Longstaff's fierce drive from the edge of the box was tipped over the crossbar by substitute Milan goalkeeper Marco Sportiello.
Howe and his team will happily take the draw and despite a number of hairy moments, the team's performance got the stamp of approval from former manager Alan Pardew.
"They've done the shirt proud tonight," he said on commentary for talkSPORT.
READ MORE ON NEWCASTLE
Rafael Leao denied 'goal of the season' against Newcastle as he trips over at last moment
I pushed trolleys at Asda after Newcastle released me, now I'm playing in Champions League
More will follow. For the latest on this and other breaking news stories, listen to talkSPORT