Zlatko Dalic's men sit top of the group at the moment and just need to avoid defeat in their final outing to secure safe passage into the knockout phase.
Meanwhile, Roberto Martinez's men are currently on the brink of elimination as they occupy third place in the group, meaning that anything less than a victory in this one would leave them relying on results elsewhere.
Here, Sports Mole looks at how the squads of Croatia and Belgium weigh up against each other ahead of Thursday's contest.
CROATIA
Most valuable player:
Josko Gvardiol (£52m)
Overall squad value:
£326.8m
Most capped player:
Luka Modric (157)
Leading goalscorer:
Andrej Kramaric (19)
Total caps:
1010
Total goals:
129
Oldest player:
Luka Modric (37)
Youngest player:
Luka Sucic (20)
Average age:
27.4
SQUAD IN FULL
Goalkeepers: Dominik Livakovic (Dinamo Zagreb), Ivo Grbic (Atletico Madrid), Ivica Ivusic (Osijek)
Defenders: Josip Stanisic (Bayern Munich), Borna Sosa (Stuttgart), Josko Gvardiol (RB Leipzig), Dejan Lovren (Zenit St Petersburg), Borna Barisic (Rangers), Domagoj Vida (AEK Athens), Josip Juranovic (Celtic), Martin Erlic (Sassuolo), Josip Sutalo (Dinamo Zagreb)
Midfielders: Luka Modric (Real Madrid), Mateo Kovacic (Chelsea), Marcelo Brozovic (Inter Milan), Mario Pasalic (Atalanta BC), Nikola Vlasic (Torino), Kristijan Jakic (Eintracht Frankfurt), Lovro Majer (Rennes), Luka Sucic (Red Bull Salzburg)
Forwards: Ivan Perisic (Tottenham Hotspur), Andrej Kramaric (Hoffenheim), Marko Livaja (Hajduk Split), Bruno Petkovic (Dinamo Zagreb), Mislav Orsic (Dinamo Zagreb), Ante Budimir (Osasuna)
BELGIUM
Most valuable player:
Kevin De Bruyne (£69.3m)
Overall squad value:
£487.7m
Most capped player:
Jan Vertonghen (144)
Leading goalscorer:
Romelu Lukaku (68)
Total caps:
1,388
Total goals:
248
Oldest player:
Jan Vertonghen (35)
Youngest player:
Zeno Debast (19)
Average age:
27.8
SQUAD IN FULL
Goalkeepers: Thibaut Courtois (Real Madrid), Simon Mignolet (Club Brugge), Koen Casteels (Wolfsburg)
Defenders: Jan Vertonghen (Anderlecht), Toby Alderweireld (Royal Antwerp), Leander Dendoncker (Aston Villa), Wout Faes (Leicester City), Arthur Theate (Rennes), Zeno Debast (Anderlecht), Yannick Carrasco (Atletico Madrid), Thomas Meunier (Borussia Dortmund), Timothy Castagne (Leicester City), Thorgan Hazard (Borussia Dortmund)
Midfielders: Kevin De Bruyne (Manchester City), Youri Tielemans (Leicester City), Amadou Onana (Everton), Axel Witsel (Atletico Madrid), Hans Vanaken (Club Brugge)
Forwards: Eden Hazard (Real Madrid), Charles De Ketelaere (AC Milan), Leandro Trossard (Brighton & Hove Albion), Dries Mertens (Galatasaray), Jeremy Doku (Rennes), Romelu Lukaku (Inter Milan), Michy Batshuayi (Fenerbahce), Lois Openda (Lens)
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