The Blues boss began his reign with a 5-0 thrashing of National League champions Wrexham on Wednesday, where the Chelsea lineup largely comprised academy products and a handful of recognisable first-teamers.
Goalkeepers Jamie Cumming and Lucas Bergstrom were among the young prospects to take part, but given the calibre of opposition on Saturday, Kepa Arrizabalaga might be recalled in between the sticks.
The same can be said of Thiago Silva in the backline, while former Brighton loanee Levi Colwill might earn some minutes too, pushing Trevoh Chalobah out of the side.
However, another ex-Seagulls defender in Marc Cucurella could lose out to Ben Chilwell on the left-hand side, while Malo Gusto holds the fort on the right until Reece James has fully recovered from illness.
Andrey Santos and Cesare Casadei lined up from the off against Wrexham, but Conor Gallagher and Enzo Fernandez may now be recalled, as Carney Chukwuemeka holds his place.
Having handed Nicolas Jackson his full debut in North Carolina, Pochettino may now bring in Christopher Nkunku for his first start, as Raheem Sterling and Ian Maatsen - who netted twice in Wednesday's win - support the Frenchman up top.
Chelsea possible starting lineup: Kepa; Gusto, Silva, Colwill, Chilwell; Gallagher, Fernandez, Chukwuemeka; Sterling, Nkunku, Maatsen
Lazio 
Atalanta 
FC Porto 
Boavista 
Udinese 
Torino 
Napoli 
Venezia 
Leicester 
Manchester City 
Everton 
Nottingham Forest 
Tottenham 
Wolverhampton 
Celtic 
ST Johnstone 
Motherwell 
Rangers 
Juventus 
Fiorentina 
West Ham 
Liverpool 
Sampdoria 
Pisa 
AC Milan 
Roma 
Sporting CP 
Benfica 
Ipswich 
Chelsea 
Manchester Utd 
Newcastle 
Brentford 
Arsenal 
Inter 
Nacional 
Valencia 
Real Madrid 
Aston Villa 
Bournemouth 
Crystal Palace 
Almeria 
Sevilla 
Bordeaux