Lopetegui left Sevilla and took charge at Molineux in November following the dismissal of Bruno Lage.
However, his future at Wolves is hanging in the balance after the Spaniard publicly criticised their lack of summer spending.
They have raised around £91million funds through player sales this summer, with Ruben Neves and Nathan Collins two notable departures.
Matheus Cunha, Boubacar Traore, Matt Doherty and Tom King have all arrived ahead of the new campaign.
Wolves managed to finish 13th and seven points clear of the relegation zone last term.
read more on transfers
Tottenham reject latest Harry Kane offer from Bayern Munich
Arsenal legend Seaman explains why Raya transfer could be good news for Ramsdale
Despite this, they could turn to former Bournemouth boss O'Neil if they opt to make a managerial change.
He was sacked by the Cherries earlier in the summer despite keeping them in the Premier League last season.
O'Neil spent the majority of the campaign at the helm after Scott Parker's departure.
A brilliant run of seven wins from nine games during the latter stages of the season kept them up, which included victories over Liverpool and Tottenham.
Most read in Football
Spurs reject Kane bid, Liverpool get another setback in Lavia chase, Raya to Arsenal
Tottenham reject latest Harry Kane offer from Bayern Munich
West Ham target rejected Salma Hayek's pleas and 'cried all day' over failed Chelsea move
I joined dream club Man United after being angry Tottenham move collapsed
However, O'Neill is yet to seal a return to management this summer after he left the south coast side.
Brighton and Liverpool are two other tough opponents during their first five fixtures, with reigning champions Manchester City welcoming them at the end of September.