The Lilywhites were humbled 4-2 at the Etihad after going 2-0 up last month, but they cruised past Preston North End 3-0 in the FA Cup fourth round last weekend thanks to Son Heung-min's brace and Arnaut Danjuma's debut goal.
Spurs enter Sunday's contest still occupying fifth place in the table - three points off the Champions League spots having played a game more than Manchester United and Newcastle United - and Cristian Stellini will take charge for the time being while Antonio Conte recovers from surgery.
Here, Sports Mole rounds up all of Tottenham's latest injury and suspension news ahead of their clash with Man City, who remain five points worse off than leaders Arsenal in second.
Richarlison
Status: Minor doubt
Type of injury: Adductor
Possible return date: February 5 (vs. Man City)
Richarlison missed the FA Cup win over Preston last weekend due to a minor problem in his adductor, but Stellini is confident that the Brazilian will be available for Sunday's game.
Pape Sarr
Status: Major doubt
Type of injury: Hip
Possible return date: February 5 (vs. Man City)
Midfield protege Pape Sarr has missed Tottenham's recent wins over Fulham and Preston with a reported hip problem, which is not expected to sideline him for long, but Sunday's game may come too soon for him to make his return.
Lucas Moura
Status: Out
Type of injury: Tendon
Possible return date: Unknown
The luckless Lucas Moura is still being plagued by a tendon issue, which will once again rule him out of Sunday's clash as he runs down the final few months of his Tottenham contract.
TOTTENHAM'S SUSPENSION LIST
Tottenham have no players suspended for this game.