The Red Devils will be bidding to claim an advantage on home soil ahead of the second leg at Estadio Ramon next week, and here Sports Mole rounds up the team news for the two sides.
MANCHESTER UNITED vs. SEVILLA
MANCHESTER UNITED
Out: Donny van de Beek (knee), Tom Heaton (ankle), Alejandro Garnacho (ankle), Marcus Rashford (groin), Luke Shaw (hamstring), Scott McTominay (unknown)
Doubtful: None
Sports Mole's predicted XI: De Gea; Dalot, Varane, L Martinez, Malacia; Casemiro, Fred, Fernandes; Antony, Martial, Sancho
SEVILLA
Out: Pape Cheikh (ineligible), Joan Jordan (Achilles), Jesus Manuel Corona (muscle)
Doubtful: None
Sports Mole's predicted XI: Bono; Montiel, Bade, Gudelj, Acuna; Fernando, Rakitic; Ocampos, Torres, Lamela; En-Nesyri
For data analysis of the most likely results, scorelines and more for this match please click here.