Los Blancos are in a strong position to reach the final eight, having recorded a 5-2 victory over Liverpool when the two teams locked horns for the reverse fixture at Anfield.
Carlo Ancelotti's side will enter the contest off the back of a 3-1 win over Espanyol in La Liga, which saw them move to within six points of leaders Barcelona in the table.
Here, Sports Mole rounds up Real Madrid's latest injury and suspension news ahead of their league clash with Liverpool, who suffered a 1-0 loss to Bournemouth last time out.
David Alaba
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
David Alaba suffered a hamstring problem in the last Champions League clash with Liverpool, and the Austria international is not expected to be back on the field until the latter stages of this month.
Ferland Mendy
Status: Minor doubt
Type of injury: Thigh
Possible return date: March 15 (vs. Liverpool)
Ferland Mendy picked up a thigh problem in the latter stages of January, which has kept him on the sidelines since, but Ancelotti said on Friday that the defender would return for this match.
Karim Benzema
Status: Minor doubt
Type of injury: Ankle
Possible return date: March 15 (vs. Liverpool)
Karim Benzema was not involved against Espanyol on Saturday due to an ankle knock that he suffered in training, but the striker is expected to return to the fold against Liverpool.
REAL MADRID'S SUSPENSION LIST
Real Madrid have no suspended players for the European contest.