The proceeds from the contest will go towards Amyotrophic lateral sclerosis research at Luzon Foundation, with former Barcelona goalkeeper and coach Juan Carlos Unzue being diagnosed with the condition two years ago.
Pep Guardiola's side will enter the contest off the back of a 3-3 draw with Newcastle United in the Premier League on Sunday afternoon.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of their contest with Barcelona, who are in the very early stages of their La Liga campaign.
Aymeric Laporte
Status: Out
Type of injury: Knee
Possible return date: Unknown
Aymeric Laporte is currently recovering from the knee operation that he underwent earlier this summer, and the centre-back is unlikely to be available for selection for another month or so.
Jack Grealish
Status: Minor doubt
Type of injury: Knock
Possible return date: August 24 (vs. Barcelona)
Jack Grealish was absent against Newcastle in the Premier League on Sunday due to a knock that he suffered against Bournemouth last weekend, but the attacker could recover in time for this contest.
Nathan Ake
Status: Major doubt
Type of injury: Muscle
Possible return date: August 24 (vs. Barcelona)
Nathan Ake was replaced in the first half of the clash with Newcastle after picking up an injury, so the centre-back has emerged as a major doubt for this game.
MANCHESTER CITY'S SUSPENSION LIST
Man City have no suspended players for this contest.