It's not going to be an easy task against Antonio Conte's men but the Reds know that, right now, Spurs don't head to Merseyside with much confidence due to recent history.
The Lilywhites haven't managed a win away against the 'mentality monsters' since May 2011.
Its an incredible stretch give some of Spurs excellent form in the 2010s which saw them have a couple of Premier League title tilts of their own under Mauricio Pochettino before Jurgen Klopp helped restore a natural order.
The 2-0 victory even saw the north Londoners leapfrog Liverpool into fifth position with one game left in the season.
Both clubs now have squads full of international superstars, whether in the starting XI or on the bench - and sometimes even left at home.
Almost 11 years ago, though, things were a little bit different and while the sides certainly had talent in them they look nothing like the clubs we see before us now.
Mind you, Tottenham's goalscorers on the day were Luka Modric - now in a fifth Champions League final - with Real Madrid, and Dutch legend Rafael van der Vaart.
Also in the Spurs team that day were heroes Ledley King, Michael Dawson, Danny Rose and Aaron Lennon.
While they were accompanied by Younes Kaboul in a rare outing at right-back, with Steven Pienaar, during an ill-fated stint at the club, on the left wing.
Carlo Cudicini was the man between the sticks, and at the opposite end of the pitch was Peter Crouch leading the line.
But who was opposing future Ballon d'Or winner Modric in midfield? Well, that day it was Lucas Leiva and Jay Spearing for Liverpool.
Under Kenny Dalglish, who was taking charge of the club permanently for the first time after his interim role replacing Roy Hodgson, the pair weren't the strongest opposition.
Joining them in midfield was Dirk Kuyt and Maxi Rodriguez, who were attempting to create for new signings Andy Carroll and Luis Suarez.
Meanwhile, attempting to halt Spurs, and ultimately failing were Pepe Reina, Jon Flanagan, Glen Johnson, Martin Skrtel, and Jamie Carragher.
But in the end they only thing they managed to stop was a streaker who cartwheeled across the Anfield turf with his club ending the season on a bum note.
Surprisingly, at the time, Tottenham boss Redknapp wasn't even keen on qualifying for the Europa League, considering it a hinderance.
Nonetheless, a 2-1 win over Birmingham City a week later confirmed their fifth-place finished as Roman Pavlyuchenko rifled in two cracking strikes - those were the days.
Now the personnel and the ambitions couldn't be further away for both clubs as a Champions League spot and a Premier League title are at stake.