Ferland Mendy, Dani Ceballos and Toni Kroos are all definitely out of the contest, while Luka Modric is unlikely to be available due to the thigh problem that saw him miss the 3-3 draw with Levante last weekend.
Marcelo and Mariano Diaz are back in full training with their teammates, though, and Nacho is also expected to be available despite missing a training session earlier this week.
Dani Carvajal made his return from injury off the bench against Levante, but Lucas Vazquez is again expected to get the nod at right-back due to the former's lack of action.
Isco could again be handed a start in midfield due to the absences of Kroos and Modric, although Marco Asensio is another option to operate in a deeper area.
Vinicius Junior scored twice off the bench last weekend and is firmly in Carlo Ancelotti's thoughts when it comes to a starting spot on Saturday night.
However, the Real Madrid boss could ultimately decide to name Gareth Bale alongside Karim Benzema and Eden Hazard in the final third, with Vinicius joining the likes of Rodrygo and Luka Jovic on the bench.
Real Madrid possible starting lineup: Courtois; Vazquez, Militao, Nacho, Alaba; Valverde, Casemiro, Isco; Hazard, Benzema, Bale