Following the match, his manager Christophe Galtier said he had a bruise or contusion but added that he is not too worried, while Sergio Ramos was also substituted in the opening half in midweek following a clash of heads which may have resulted in a concussion.
The status of Ramos remains unknown, and it adds to the list of players on this team who might not be 100% as Presnel Kimpembe is out until the middle of February with an Achilles tendon problem, while Neymar sat out on Wednesday because of muscular fatigue.
Midfielder Marco Verratti is eligible to return after serving his red card suspension, and Nordi Mukiele remains sidelined due to a hamstring strain.
With a last-16 Champions League clash against Bayern Munich scheduled in a couple of weeks, Galtier might not want to risk playing Mbappe even if his injury is not severe, which could open the door for Hugo Ekitike to start a domestic fixture for the first time since the middle of January.
Ramos was replaced by Renato Sanches versus Montpellier, while Juan Bernat came on for Nuno Mendes for the final 20 minutes of that encounter.
Lionel Messi fired home his second goal in Ligue 1 this year, Fabian Ruiz notched early in the second half and Warren Zaire-Emery made history, becoming the youngest player to ever score for them in this competition at 16 years and 330 days.
Paris Saint-Germain possible starting lineup: Donnarumma; Mendes, Pembele, Marquinhos, Hakimi; Verratti, Pereira, Vitinha, Soler; Ekitike, Messi