Spurs suffered a 2-1 home loss to Wolverhampton Wanderers in their last match on February 17, with the result leaving them in fifth position in the Premier League table.
The capital outfit are three points clear of sixth-placed Manchester United and five points behind fourth-placed Aston Villa, with a game in hand on both teams.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of the clash with Palace, who will enter the match off the back of a 3-0 home win over Burnley.
Pedro Porro
Status: Out
Type of injury: Strain
Possible return date: March 10 (vs. Aston Villa)
Porro was not available for the clash with Wolves due to a muscular problem, and the right-back is again set to miss out this weekend, with his return potentially coming against Aston Villa.
Destiny Udogie
Status: Minor doubt
Type of injury: Knee
Possible return date: March 2 (vs. Crystal Palace)
Udogie was forced off with a knee injury against Brighton & Hove Albion earlier this month, but the full-back is now back in training and therefore in contention to make his return this weekend.
Fraser Forster
Status: Out
Type of injury: Foot
Possible return date: Unknown
Forster suffered a foot fracture in a recent training session, and the club's number two goalkeeper is not expected to be back on the training field until the end of April.
Manor Solomon
Status: Out
Type of injury: Knee
Possible return date: Unknown
Solomon was recently forced to undergo another procedure on his knee, although he is expected to be available for selection before the end of the 2023-24 campaign.
Ryan Sessegnon
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Sessegnon returned in January after undergoing a hamstring operation over the summer, but the left-back has now been forced to undergo further hamstring surgery after suffering an injury while representing the club's Under-23s side, and he is now likely to miss the rest of the season.
TOTTENHAM HOTSPUR'S SUSPENSION LIST
Tottenham have no players suspended for this match.
Nizhny Novgorod 
CSKA Moscow 
Espanyol 
Oviedo 
Bologna 
Juventus 
Tottenham 
Newcastle 
Atalanta 
Bayer Leverkusen 
Baltika 
Lokomotiv Moscow 
Ural 
Orenburg 
Spartak Moscow 
Manchester Utd 
Manchester City 
Celtic 
Rangers 
Polissya Zhytomyr 
Shakhtar Donetsk 
Rukh Lviv 
Dynamo Kyiv 
FC Kaiserslautern 
Lyon 
Paris Saint Germain 
Real Madrid 
Betis 
Real Sociedad 
Atletico Madrid 
Celta Vigo 
Valencia 
AC Milan 
Salernitana 
Cagliari 
Fiorentina 
Empoli 
Roma 
Frosinone 
Udinese 
Monza 
Lazio 
Sassuolo 
Napoli 
Lecce 
Verona 
Inter 
FC Porto 
Sporting CP 
Amorebieta 
Sevilla 
Barcelona 
Olympiacos Piraeus