And there was something for Manchester United fans to savour, too, with loanee Facundo Pellistri and veteran striker Edinson Cavini also helping to inspire La Celeste on Tuesday night.
Within a minute, midfielder Bentancur opened the scoring with a stunning effort from range, just 24 hours after sealing a £15.8million deadline day move from Juventus to Spurs.
The hosts' lead was doubled by Giorgian de Arrascaeta on 23 minutes, after Man United loanee Pellistri put the ball on a plate for his teammate with some brilliant work.
It was a first international goal contribution for Pellistri, the 20-year-old winger struggling on loan at LaLiga club Alaves, who was getting his second cap.
His Red Devils colleague Cavani, on the other hand, has already made 128 appearances for his country and netted his 54th goal on Tuesday night.
The 34-year-old turned an overhead kick into an empty net in first-half stoppage time to all-but end the visitors' hopes.
Cavani's partner in crime, Luis Suarez, also managed to get in on the act, although he required two bites at the cherry after Pellistri won a penalty in the 53rd minute.
The Atletico Madrid striker missed with his first spot-kick, but made no mistake when given the opportunity to retake.
Venezula pulled one back via Josef Martinez on 65 minutes, but their position at the bottom of CONMEBOL World Cup qualifiers was not about to change.
Uruguay, meanwhile, leapfrog Peru and Chile into fourth position and look well poised to reach Qatar 2022.