The two teams require points for completely different goals, with the hosts pushing away from the relegation zone, while the visitors are attempting to secure a European place.
Match preview
Sitting just five points above the relegation zone the pressure is on Kayserispor to try and secure three points on Wednesday as they aim to solidify their status in the division for next season.
Burak Yilmaz was left disappointed after their most recent outing against Alanyaspor as he witnessed his team concede in the 103rd minute of the game to lose 1-0.
It continued Kayserispor's recent dry patch in front of goal, scoring just once in their previous three matches, which has been a period where they have only picked up a single point.
While Yilmaz has steadied things since he took charge of the club there is still more work to be done to secure survival, with the run-in providing plenty of pressure.
However, Kayserispor did manage to take all three points the last time they met Kasimpasa, coming out on top of a seven-goal thriller.
While a match as entertaining as that would be great for the neutrals, it is the last thing the visitors will be hoping for given they are making a late push to try and secure a place in the top four.
Kasimpasa currently sit just three points behind Besiktas, but they have been lacking in consistency lately which could prove to be decisive in their attempts to finish in a European position.
Sami Ugurlu's men have only won two of their previous six matches, with a couple of draws and defeats taking place in that run, with their most recent outing producing a match to forget.
Even though they had fought back from behind twice in the game to lead 3-2, Kasimpasa went on to lose against Galatasaray when Carlos Vinicius scored a 90th-minute winner.
With time running out this season, the focus will be on trying to string a set of results together in a bid to place as much pressure on those above them as possible.
Kayserispor Turkish Super Lig form:
D
W
W
L
D
L
Kasimpasa Turkish Super Lig form:
W
D
L
D
W
L
Team News
Kayserispor could welcome back Gokhan Sazdagi for this game after serving his suspension, which might lead to him slotting straight back in at full-back.
However Anthony Uzodimma and Majid Hosseini will still be out of action with long-term injuries, with neither expected back in the near future.
The visitors will be without Claudio Vinck on Wednesday night as he kickstarts his suspension after being red-carded in their most recent outing.
Dries Saddiki is also expected to be missing due to a hamstring problem, but Wednesday could mark the return of Erdem Cetinkaya, who has been pushing close to full fitness recently.
Kayserispor possible starting lineup:
Bayazit; Kaldirim, Kolovetsios, Attamah, Carole; Yilmaz, Bourabia; Civelek, Karimi, Cardoso; Nazon
Kasimpasa possible starting lineup:
Gianniotis; Gedik, Ciftpinar, Ozcan, Omeruo; Guel, Kara; Fall, Hajradinovic, Caglayan; Da Costa
We say: Kayserispor 0-2 Kasimpasa
Kayserispor might have taken all three points the last time these two teams met, but they will certainly head into this game as the underdogs.
Considering Kasimpasa's league position, their stronger squad should lead to them picking up a comfortable win.