The Red Devils have progressed past Wigan Athletic, Newport County and Nottingham Forest to reach the last eight, where star striker Rasmus Hojlund is on track to make his return from a muscle injury.
In addition, Ten Hag has expressed hope that Harry Maguire and Aaron Wan-Bissaka can be involved too - the former has been called up to the England squad for their upcoming friendlies with Brazil and Belgium,
However, Anthony Martial (groin), Luke Shaw (muscle), Tyrell Malacia (knee) and Lisandro Martinez (knee) are still confined to the infirmary, while Omari Forson also picked up an unspecified issue prior to the win over Everton last weekend.
With Hojlund expected to take his place at the tip of the attack, Scott McTominay could vacate his spot in the XI for the returning Dane, who ought to join Bruno Fernandes, Marcus Rashford and the tricky Alejandro Garnacho in the final third.
The latter became the first Man United player to win two penalties in a single Premier League game last weekend, where Kobbie Mainoo - fresh from a first call-up to England's Under-21s - and Casemiro paired up in midfield and should do so again here.
Maguire's potential return in defence could see Jonny Evans drop out, but as Wan-Bissaka has been out for significantly longer, Ten Hag may avoid risking the right-back and stick with Diogo Dalot and Victor Lindelof as his wide options for now.
Manchester United possible starting lineup:
Onana; Dalot, Varane, Maguire, Lindelof; Mainoo, Casemiro; Garnacho, Fernandes, Rashford; Hojlund