As well as losing the game to Everton last weekend, Chelsea lost all of Reece James (hamstring), Robert Sanchez (knee) and Marc Cucurella (ankle) at various points in that 2-0 Goodison Park defeat.
While the severity of Sanchez and Cucurella's injuries have not been disclosed, James is expected to remain out for several weeks with his latest blow, as he takes his usual place in the treatment room alongside Trevoh Chalobah (thigh), Lesley Ugochukwu (unspecified), Wesley Fofana (knee), Ben Chilwell (thigh) and Carney Chukwuemeka (knee).
Romeo Lavia (ankle), Christopher Nkunku (knee), Noni Madueke (unspecified) and Malo Gusto (tendon) are all on the touch-and-go list at the time of writing, and should the latter not be given the green light to play, Axel Disasi will be expected to step in at right-back.
Disasi being shifted across the backline would open the door for Thiago Silva to return alongside Benoit Badiashile, while Levi Colwill is primed to step in for Cucurella, and the back four may very well be protecting Djordje Petrovic if Sanchez misses out.
The hosts' backline is set to undergo a major reshuffle, but the midfield pairing of Enzo Fernandez and Moises Caicedo remains untouchable, while Conor Gallagher is set to don the captain's armband in place of the stricken James.
Cole Palmer's spot in attack is safe, but Mykhaylo Mudryk and Armando Broja are in danger of losing their places to Raheem Sterling and Nicolas Jackson, who has apparently escaped retrospective action for a set-to with Everton's Nathan Patterson last weekend.
Chelsea possible starting lineup: Petrovic; Disasi, Silva, Badiashile, Colwill; Fernandez, Caicedo; Sterling, Gallagher, Palmer; Jackson