The Catalans have won five league games in a row to move within two points of Real Madrid, who play 24 hours later than their fierce rivals, with the two sides meeting at Camp Nou in El Clasico in two weeks' time.
However, Xavi's side have been rocked by several injuries during the international break, with Memphis Depay, Frenkie De Jong and Jules Kounde each sustaining muscle injuries for their country.
As such, Raphinha, Sergio Busquets and Sergi Roberto are likely to replace the trio from the 3-0 win against Elche two weekends ago, with Hector Bellerin's calf injury leaving Xavi short of options at right-back.
Ronald Araujo underwent surgery on a serious thigh issue earlier this week and is unlikely to play again before the World Cup, with Andreas Christensen potentially partnering Eric Garcia at the heart of the defence should Gerard Pique remain out of favour with his former teammate.
Franck Kessie will hope to edge out Gavi for a spot in midfield, while Robert Lewandowski will be looking to score for the sixth successive league match having hit the ground running in Spain.
Barcelona possible starting lineup: Ter Stegen; Roberto, Christensen, Garcia, Alba; Kessie, Busquets, Pedri; Dembele, Lewandowski, Raphinha
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