Trailing 3-0 from a shock first-leg loss at Anfield, the Reds suffered back-to-back defeats in a 1-0 beating at the hands of Crystal Palace in Sunday's Premier League clash, where Conor Bradley came off early in the second half with a foot problem.
It is still unclear how serious the right-back's injury is, but Klopp admitted that the issue was a "very painful" one, so Bradley ought to be one of four injury victims watching on from the sidelines this week.
Ben Doak (knee), Joel Matip (knee) and Thiago Alcantara (muscle) are absent too, but Stefan Bajcetic is finally available again after a troublesome calf problem and earned some minutes for the Under-21s last week.
Bajcetic is an option to replace Bradley at right-back, but Trent Alexander-Arnold will surely return to the rearguard alongside Ibrahima Konate, Virgil van Dijk, Alisson Becker and Andrew Robertson, arguably the only Liverpool player to do himself justice at the weekend.
Wataru Endo and Curtis Jones both left a lot to be desired in the middle, so Harvey Elliott and Dominik Szoboszlai could now freshen up the engine room, where Alexis Mac Allister may occupy the deepest position again.
Possessing a big-chance conversion rate of 19.4% - the worst of any player in the big five European leagues - Darwin Nunez risks ceding his spot to the fit-again Diogo Jota, but Mohamed Salah and Luis Diaz should reprise their roles out wide.
Liverpool possible starting lineup:
Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Szoboszlai, Mac Allister, Elliott; Salah, Jota, Diaz