The Blues were the better team for large parts of their FA Cup semi-final with Manchester City, but they failed to put away their chances and ultimately fell to a 1-0 defeat at Wembley courtesy of Bernardo Silva's late goal.
All focus is now on the fight for European football for Mauricio Pochettino's side, who destroyed Everton 6-0 in their last top-flight fixture and lie ninth in the table, within touching distance of Manchester United, Newcastle United and West Ham United.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of the showdown with Arsenal, who overcame Wolverhampton Wanderers 2-0 on Saturday night.
Robert Sanchez
Status: Major doubt
Type of injury: Illness
Possible return date: April 23 (vs. Arsenal)
Robert Sanchez was again absent from the ranks to face Man City due to an illness, although he has resumed parts of team training and might be given the green light to make the trip to North London.
Levi Colwill
Status: Major doubt
Type of injury: Toe
Possible return date: April 23 (vs. Arsenal)
Levi Colwill has been dealing with a troublesome toe problem for several weeks and was not ready to make his comeback at Wembley, but he is taking part in light training and might make the bench in North London.
Christopher Nkunku
Status: Out
Type of injury: Hamstring
Possible return date: May 2 (vs. Tottenham Hotspur)
Christopher Nkunku is also being put through his paces gradually in training as he enters the final stages of his rehabilitation from a hamstring concern, which might clear up in time for him to return in early May.
Wesley Fofana
Status: Out
Type of injury: Knee
Possible return date: Unknown
The hapless Wesley Fofana remains glued to the treatment table due to his serious knee injury, and Pochettino has conceded that he does not envisage the Frenchman returning before the end of the season.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Similarly, captain Reece James is on the recovery trail from hamstring surgery, and no timeframe has been placed on his recovery, so he could very well miss the remainder of the campaign too.
Lesley Ugochukwu
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Lesley Ugochukwu, who is yet to appear in 2024 due to a hamstring injury, is still a few weeks away from a potential return to first-team training, so he will likely be missing until next season too.
Romeo Lavia
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Romeo Lavia's debut season at Chelsea will end with just one appearance to his name, as the Belgian is nursing a severe thigh problem and has already been ruled out until the 2024-25 season.
CHELSEA'S SUSPENSION LIST
Chelsea have no players suspended for this match.